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  • 1
    Electronic Resource
    Electronic Resource
    Analgesic effects of propyphenazone in comparison to its combination with caffeine (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 377-382 
    Details
    ISSN: 1432-1041
    Keywords: Phasic pain ; Carbon dioxide ; irritation ; chemical stimulation ; chemo-somatosensory event-related potential ; analgesia ; caffeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The aim of the study was to investigate whether the analgesic effect of propyphenazone (PROP) was increased when it was administered in combination with caffeine (CAFF). Methods: For assessment of analgesia a model was chosen based on chemo-somatosensory event-related potentials (CSSERP) elicited by stimulation of the nasal mucosa. Twenty healthy volunteers participated in the experiments. The study followed a placebo-controlled, randomised, double-blind, 5-fold cross-over design. Each of the 5 medications (400 mg PROP, 600 mg PROP, 400 mg PROP+100 mg CAFF, 600 mg PROP+150 mg CAFF, placebo) was orally administered. Experiments were separated by at least 5 days. In addition to assessment of CSSERP, subjects estimated the intensity of the stimulus. Drug effects unrelated to nociception were monitored, and in addition, the plasma levels of PROP were also analysed. Results: While 400 mg PROP did not significantly reduce the amplitude of CSSERP in comparison to placebo, all other medications produced a significant decrease in amplitudes. For both dosages of PROP, there was a significant amplification of the antinociceptive effect of PROP by CAFF, as indicated by the decrease in CSSERP amplitude. A significant effect of the factor “drug” was also found in the spontaneous EEG, indicating an arousal reaction after CAFF. No significant differences between plasma levels of PROP were found when applied either alone or in combination with CAFF. Conclusion: The significant increase in the antinociceptive effect of PROP when administered together with caffeine appears to be related either to amplification of PROP's antinociceptive actions by CAFF or an atinociceptive effect of CAFF itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203781
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Tonic versus phasic pain: dose-related effects of ketoprofen (1995)
    Springer
    European journal of clinical pharmacology 49 (1995), S. 7-14 
    Details
    ISSN: 1432-1041
    Keywords: Tonic pain ; Phasic pain ; Irritation ; Chemical stimulation ; chemo-somatosensory event-related potential ; non-steroidal anti-inflammatory drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Only recently has a new experimental technique been developed which combines tonic and phasic painful stimulation. By means of this technique the non-steroidal anti-inflammatory drug (NSAID) ibuprofen has been shown to produce a dose-related decrease in heterotopically applied phasic and tonic pain. The present study aimed to investigate the dose-related pain. The present study aimed to investigate the dose-related effects of the NSAID ketoprofen (50, 100, and 150 mg i.v.) when tonic and phasic stimuli were applied homotopically. Eighteen healthy volunteers participated in the double-blind, randomized, placebo-controlled study. After an initial training session subjects took part in four experiments, each of which was divided into three sessions (before, 30, and 120 min after drug administration). During each session 45 painful phasic CO2 stimuli of three concentrations were presented to the left nostril in randomized order (duration 200 ms; interval 40 s; 45%, 52%, and 59% v/v CO2). The left nostril was additionally stimulated with a constant stream of dry air, which produced a tonic painful sensation described as dull and burning. Subjects rated the intensity of the painful stimuli by means of visual analogue scales. Chemosomatosensory event-related potentials (CSSERPs) were recorded in response to phasic painful CO2 stimuli. Ketoprofen reduced the subjects' estimates of tonic pain in a dose-related manner. In contrast, given the special conditions of homotopic application of tonic and phasic painful stimuli, estimates of phasic pain increased significantly, corresponding to a significant increase in CSSERP amplitudes. An explanation of this inverse effect of the drug on responses to tonic and phasic pain may be a lateralized interaction between both C-fiber and Aδ-fiber systems at a spinal or peripheral level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192351
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Analgesic effects of propyphenazone in comparison to its combination with caffeine (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 377-382 
    Details
    ISSN: 1432-1041
    Keywords: Key words Phasic pain ; Carbon dioxide; irritation ; chemical stimulation ; chemo-somatosensory event-related potential ; analgesia ; caffeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract. Objective: The aim of the study was to investigate whether the analgesic effect of propyphenazone (PROP) was increased when it was administered in combination with caffeine (CAFF). Methods: For assessment of analgesia a model was chosen based on chemo-somatosensory event-related potentials (CSSERP) elicited by stimulation of the nasal mucosa. Twenty healthy volunteers participated in the experiments. The study followed a placebo-controlled, randomised, double-blind, 5-fold cross-over design. Each of the 5 medications (400 mg PROP, 600 mg PROP, 400 mg PROP + 100 mg CAFF, 600 mg PROP + 150 mg CAFF, placebo) was orally administered. Experiments were separated by at least 5 days. In addition to assessment of CSSERP, subjects estimated the intensity of the stimulus. Drug effects unrelated to nociception were monitored, and in addition, the plasma levels of PROP were also analysed. Results: While 400 mg PROP did not significantly reduce the amplitude of CSSERP in comparison to placebo, all other medications produced a significant decrease in amplitudes. For both dosages of PROP, there was a significant amplification of the antinociceptive effect of PROP by CAFF, as indicated by the decrease in CSSERP amplitude. A significant effect of the factor “drug” was also found in the spontaneous EEG, indicating an arousal reaction after CAFF. No significant differences between plasma levels of PROP were found when applied either alone or in combination with CAFF. Conclusion: The significant increase in the antinociceptive effect of PROP when administered together with caffeine appears to be related either to amplification of PROP’s antinociceptive actions by CAFF or an atinoci ceptive effect of CAFF itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050035
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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