ISSN:
1573-7373
Keywords:
malignant glioma
;
recurrent
;
chemotherapy
;
interferon
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Recombinant interferon beta (IFN-βser) has been administered by intravenous bolus injection three times weekly at a dose of 90 × 106 IU to 14, patients with recurrent malignant glioma in an ongoing study. The treatment period has ranged from 1 to 40 weeks. The most common adverse experiences were fever, chills, malaise, and headache. Fever, chills and headache were worse with the first two doses and were usually relieved with acetaminophen. All patients tolerated subsequent treatments without any difficulties. No neurologic or hematologic toxicities were observed. Of ten evaluable patients, five had progressive disease in 4 to 8 weeks; three had stable disease for 12 to 21 weeks; one has had a minor response for 13 weeks; and one has had a complete resolution of tumor for 150 + weeks. IFN-βser appears to have activity in human glioma and is well tolerated at this dosage and schedule.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00167065
Permalink
