ISSN:
0021-9304
Keywords:
composites
;
ceramic polymer drug
;
ibuprofen release
;
alumina
;
poly(L-lactic acid)
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
The preparation, characterization, and in vitro release of Ibuprofen from Al2O3, poly(L-lactic acid) (PLLA), and polymethylmethacrylate (PMMA) composites are described. The release process of the anti-inflammatory drug after the immersion of composites in a buffered solution is analyzed. The rate of Ibuprofen release is related to the crystalline or amorphous form of the drug. The presence of a ceramic component, α-Al2O3, and a biodegradable polymer, PLLA, facilitates both Ibuprofen crystallization and drug release. In addition, these composite systems modulate the release of the stereoisomers R(-) and S(+) of the drug. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 423-428, 1998.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
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