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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of in Vitro Dissolution of Whole vs. Half Controlled-Release Theophylline Tablets (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 416-419 
    Details
    ISSN: 1573-904X
    Keywords: controlled-release theophylline ; dissolution ; whole vs. half tablets ; statistical analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Controlled-release (CR) drug products dissolve more slowly than conventional-release products, reflecting their quality of sustaining a prolonged therapeutic effect. A frequent practice with scored tablets when only half the dosage is desired is to divide the tablet at the score mark and administer only half of the product. The dissolution characteristics of the divided tablets are unknown. It is only an assumption that the halved tablet behaves similarly to the whole tablet both in vitro and in vivo. A series of in vitro dissolution analyses was performed on whole and half CR theophylline tablets from different manufacturers. Statistical tests were carried out between the dissolution results of whole and those of halved tablets to determine whether the mean overall percentages dissolution (averaged over sampling times) were similar and whether the patterns of percentage dissolution over time were similar. The dissolution of halved tablets was slightly faster compared to that of intact (whole) tablets. However, these small differences were not large enough to cause concern or to require bioavailability studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016442514205
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In Vitro Dissolution Profile of Water-Insoluble Drug Dosage Forms in the Presence of Surfactants (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 612-618 
    Details
    ISSN: 1573-904X
    Keywords: dissolution of water-insoluble drugs ; dissolution of griseofulvin, carbamazepine, clofibrate, medroxyprogesterone, cortisone acetate ; dissolution with sodium lauryl sulfate ; dissolution with surfactants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The determination of the in vitro release profile of water-insoluble drug products requires dissolution media different from those used for water-soluble drug products. Since the relevance of drug dissolution in organic solvents is questionable, we investigated the use of surfactants to determine the dissolution profiles of water-insoluble drug products. In most cases, the drug dissolution rate and extent increased as the surfactant concentration in the aqueous dissolution medium increased. Suitable dissolution profiles were obtained in the presence of sodium lauryl sulfate (SLS) for water-insoluble drug products, such as griseofulvin, carbamazepine, clofibrate, medroxyprogesterone, and cortisone acetate. These findings recommend the use of surfactants for determining the aqueous dissolution of water-insoluble drug products rather than adding organic solvents to the dissolution medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015909716312
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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