ISSN:
1432-0428
Keywords:
Keywords Diabetes mellitus
;
glycation
;
cross-links
;
vascular stiffening.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Previous studies have shown that biomechanical analysis of aorta from diabetic subjects reveals a marked increase in stiffness compared to aorta from age-matched control subjects. In the present paper we have proposed that this increased stiffness can be attributed to glycation-induced inter-molecular cross-links based on a direct analysis of the two known glycation cross-links, the fluorescent pentosidine and the non-fluorescent NFC-1. There was a significant difference in the increase in concentration of both cross-links with increasing age for both the intima (p 〈 0.0025) and the media (p 〈 0.0005) from the diabetic compared to the control subjects, but no correlation with the mature enzymic cross-link hydroxylysyl-pyridinoline. Finally, we have obtained a significant correlation of stiffness with both glycation cross-links (NFC-1, r = 0.86; p 〈 0.005 and pentosidine r = 0.75, p 〈 0.05), but the concentration of NFC-1 is about 50 times greater than that of pentosidine, indicating that it is the major glycation cross-link responsible for the stiffening of the aorta. [Diabetologia (1996) 39: 946–951]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00403914
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