ISSN:
0006-3592
Keywords:
cybernetic modeling
;
biosynthetic precursors
;
metabolic regulation
;
enzyme synthesis
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Growth of microorganisms on substitutable substrate mixtures display diverse growth dynamics characterized by simultaneous or preferential uptake of carbon sources. This article shows that cybernetic modeling concepts which were successful in predicting diauxic growth patterns can be extended to describe simultaneous consumption of substrates. Thus the growth of Escherichia coli on mixtures of glucose and organic acids such as pyruvate, fumarate, and succinate has been described successfully by the cybernetic model presented here showing both diauxic and simultaneous uptake when observed. The model also describes the changes in utilization patterns that occur under changing dilution rates, substrate concentrations, and models of preculturing. The model recognizes the importance of the synthesis of biosynthetic precursors in cell growth through a kinetic structure that is quite general for any mixture of carbon-energy sources. © 1996 John Wiley & Sons, Inc.
Additional Material:
14 Ill.
Type of Medium:
Electronic Resource
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