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  • 1
    Electronic Resource
    Electronic Resource
    Effect of misoprostol on histamine-stimulated acid secretion and cyclic AMP formation in isolated canine parietal cells (1987)
    Springer
    Digestive diseases and sciences 32 (1987), S. 1010-1016 
    Details
    ISSN: 1573-2568
    Keywords: misoprostol ; PGE ; methylester ; parietal cells ; acid secretion ; cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isolated canine parietal cells were used to study the ability of misoprostol to inhibit acid secretion in the presence of a number of acid secretagogues. Misoprostol inhibited histamine-stimulated acid secretion in a dose-dependent and noncompetitive manner. A concentration of 2–3×10−9 M misoprostol inhibited maximal histamine-stimulated acid secretion by one half. Misoprostol had little to no effect on acid secretion stimulated by carbachol and dibutyryl cAMP, had no effect on the acid secretion directly stimulated by pentagastrin, and only modestly inhibited acid secretion stimulated by forskolin. Misoprostol noncompetitively inhibited cAMP formation in response to histamine, with an IC50 value similar to that for the inhibition of histamine-stimulated acid secretion. These results indicate that: (1) misoprostol specifically inhibits histamine-stimulated acid secretion in parietal cells, and (2) the antisecretory action of misoprostol is closely related to the reduction of histamine-stimulated cAMP formation with the site of major action most likely in the coupling process between histamine H2 receptor sites and histamine-sensitive adenylate cyclase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297192
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of gastric antisecretory and prostaglandin E receptor binding activity of misoprostol by misoprostol free acid (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 588-593 
    Details
    ISSN: 1573-2568
    Keywords: misoprostol ; misoprostol free acid ; PGE receptor binding ; antisecretory activity ; prodrug ; parietal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In enriched canine parietal cell preparations, misoprostol, an analog of prostaglandin E1 methyl ester, was rapidly deesterified to misoprostol free acid. Under this circumstance, misoprostol and misoprostol free acid exhibited equal antisecretory potency against histamine-stimulated acid secretion and bound equally well to prostaglandin E receptors. When the deesterification of misoprostol was inhibited by paraoxon, an esterase inhibitor, the antisecretory and receptor binding activity of misoprostol was markedly reduced, with potency much less than misoprostol free acid. These results indicate that misoprostol free acid is the active biological form of misoprostol that binds to prostaglandin E receptors and mediates the antisecretory action of misoprostol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297024
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Dual-wavelength radiation thermometry: Emissivity compensation algorithms (1990)
    Springer
    International journal of thermophysics 11 (1990), S. 269-281 
    Details
    ISSN: 1572-9567
    Keywords: dual-wavelength radiation thermometry ; emissivity ; pyrometry ; radiation thermometry ; radiometry ; surface characterization ; temperature ; measurement ; x-ray photoelectron spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The traditional contact methods of temperature measurement for metal processing applications provide accuracies of ±10 K. Noncontact methods based upon emissivity compensation techniques have the potential for improved accuracy with greater ease of use but require prior knowledge of the target emissivity behavior. The features of the basie spectral and ratio methods and five dualwavelength methods are reviewed. Experiments were conducted on a series of aluminum alloys with different surface treatments characterized by x-ray photoelectron spectroscopy in the temperature range 600 to 750 K. Compensation algorithms that account for surface characteristics are required to achieve improved accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00503877
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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