ISSN:
1573-8221
Keywords:
GABA
;
morphine
;
cyclic nucleotides
;
opiate receptors
;
bicuculline
;
thiosemicarbazide
;
analgesia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In order to detect possible interaction between GABA and opiates, the effects of GABA-ergic drugs on analgesia induced by morphine were studied. The vocalization response to electrical stimulation of the tail in rats was used as an index of the action of morphine. Thiosemicarbazide, an inhibitor of glutamate decarboxylase, and bicuculline, which blocks GABA-ergic receptors, drugs which, it is suggested, can be considered as a group of GABA-negative compounds, weaken and shorten the effect of morphine. Depakine, an inhibitor of α-ketoglutarate-GABA-transaminase, like GABA itself, given in large doses (GABA-positive effects) strengthens morphine analgesia and prolongs its effect. The possible causes of these relations between GABA and opiates are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00804772
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