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  • 1
    Electronic Resource
    Electronic Resource
    α1-Adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations: preservation in multi-infarct dementia and dementia of Alzheimer typereceptor binding sites in post-mortal human cerebral microvessel preparations: preservation in multi-infarct dementia and dementia of Alzheimer type (1989)
    Springer
    Journal of neural transmission 1 (1989), S. 303-310 
    Details
    ISSN: 1435-1463
    Keywords: Human brain ; cerebral microvessels ; multi-infarct dementia ; dementia of Alzheimer type ; α1-adrenergic receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral cortical microvessels were prepared from control, dementia of Alzheimer type (AD/SDAT) and multi-infarct dementia (MID) autopsy cases. The microvessel yields were approx. 200 μg protein/g starting material, and did not differ significantly between control, MID and AD/SDAT groups. The purity of the preparations was confirmed both by light and electron microscopy and by measurement of enrichment of the endothelial markers γ-glutamyltranspeptidase and alkaline phosphatase. Higher microvessel alkaline phosphatase activities and higher microvessel/homogenate ratios of activities of both enzymes in the MID and the AD/SDAT samples than in the control samples were found, which may be consistent with previous findings of structural abnormalities of the cerebral endothelial cells in AD/SDAT. The levels of [3H] prazosin binding did not differ significantly between control, MID and AD/SDAT samples at any [ligand] tested (0.05, 0.1, and 0.5 nM), suggesting conservation of microvessel α1-adrenoceptors in MID and AD/SDAT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263484
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EEG-microstates in mild memory impairment and Alzheimer's disease: possible association with disturbed information processing (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 483-495 
    Details
    ISSN: 1435-1463
    Keywords: EEG ; microstates ; segmentation ; cognitive dysfunction ; dementia of Alzheimer type ; information processing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The only available functional neuroimaging methods reaching the time resolution of human information processing are EEG and MEG. Since spectral analysis implies analysis of longer time epochs, the high temporal resolution of EEG is partly lost. By dividing the EEG in the time-domain into segments of similar spatial distribution on the scalp (microstates) it has been possible to assess patterns of neuronal activity representing the information process currently performed by the brain. In the present study alterations of EEG microstates in subjective (n=31) and objective (n=38) memory impairment as well as in probable Alzheimer disease (DAT: n=64) compared to healthy controls (n=21) were investigated. The main findings were reduced segment durations and a more anterior center of gravity of the microstate topography in DAT. With more pronounced cognitive dysfunction larger window sizes were found. Shorter microstates and larger windows reflect more rapidly changing spatial activation patterns, and are interpreted as an impaired capability to establish stable brain states necessary for normal brain function. The anteriorization of the microstates is consistent with results in the frequency domain and may reflect neuropathological changes in DAT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277666
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    Paper (German National Licenses)
    Fulltext
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