Electronic Resource
New York, N.Y.
:
Wiley-Blackwell
Journal of Cellular Biochemistry
45 (1991), S. 54-58
ISSN:
0730-2312
Keywords:
programmed cell death
;
development
;
spermidine
;
spermine
;
acetylase
;
oxidase
;
peroxide
;
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Mammalian cells can rapidly make large changes in their rate of polyamine biosynthesis in response to mitogenic and trophic signals. However, cultured cells seem to grow adequately as long as they are supplied a steady but unregulated supply of polyamines. This implies that complex and rapid changes in polymine synthesis serve a function in a special rather than a general biological context. We suggest that the appropriate context in which regulation of polyamines mediates crucial functions is the mammalian embryo and that one function of polyamines is to act as substrate in an oxidative pathway that arbitrates programmed cell death.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcb.240450112
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