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  • 1
    Electronic Resource
    Electronic Resource
    Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation (1983)
    Springer
    Diabetologia 25 (1983), S. 97-107 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas ; transplantation ; injection of neoprene ; diabetes ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The injection of neoprene into the pancreatic ducts of dogs has been used to destroy exocrine function prior to pancreatic transplantation. The subsequent histological changes and the evolution of lesions over a period of 3–36 months are described. Animals were sacrified or biopsied at various intervals (3, 15 and 36 months) and the pancreases showed the disappearance of exocrine acini and changes of chronic pancreatitis. An immunoperoxidase procedure with insulin, glucagon, somatostatin and pancreatic polypeptide antisera was used to show the persistence of pancreatic endocrine cells. After the injections, sclerosis progressively increased and secondary lesions of the islets were seen, although functional islets persisted. This technique was then applied to pancreas transplantation in man. Eight transplants from seven diabetic patients were available for examination. In four cases, there were early technical failures, but four pancreatic transplants continued to function for 28–889 days until suppuration destroyed one of the grafts and the three other patients died. The persistence of endocrine cells in sclerotic tissue was observed in histological and immunopathological examinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250896
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thirty months' experience with cyclosporin in human pancreatic transplantation (1984)
    Springer
    Diabetologia 27 (1984), S. 154-156 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; cyclosporin ; pancreatic transplantation ; renal transplantation ; immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between September 1978 and December 1983, 33 simultaneous kidney plus pancreatic transplantations were performed in Type 1 (insulin-dependent) diabetic patients with uraemia at the Herriot Hospital, Lyon. In eight patients grafted before June 1981, immunosuppressive treatment consisted of azathioprine, steroids and a temporary course with anti-lymphocyte globulins (protocol A). Since June 1981, the immunosuppressive treatment has consisted of cyclosporin administered according to two protocols: from the day of transplantation with temporary anti-lymphocyte globulins with or without steroids (protocol B, seven patients), or after an initial course with protocol A, with or without steroids (protocol C, 18 patients). Only slight differences in patient and pancreatic graft survival between the three protocols were observed at 3, 6 and 12 months, while an improved survival rate for both patients and pancreatic grafts was observed in protocols B and C at 2 years. Moreover the incidence of pancreatic rejection as a cause of loss of pancreatic function seemed to be reduced under protocols B and C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275676
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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