ISSN:
1573-2622
Keywords:
fluorophotometry
;
blood retinal barrier
;
permeability
;
blood aqueous barrier
;
diffusion coefficient
;
diabetic retinopathy
;
fluorescein angiography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The permeability of the blood retinal barrier (PBRB) and the diffusion coefficient into the anterior chamber (kd) in 20 insulin dependent (ID) and in 11 non-insulin dependent (NID) diabetics with various degrees of retinopathy were determined by fluorophotometry with a 25% accuracy. The difference of PBRB and the kd values between the NID and the ID patients was not significant (p 〉 0.05 and p 〉 0.22). The mean PBRB and the mean kd values differed significantly from those of a healthy population (p 〈 0.0013 and p = 0.025). A significant correlation was established between PBRB and diabetes duration (r = 0.55; p 〈 0.01) but not between PBRB or kd values and metabolic control (HbA1) (p 〉 0.5) or creatinine clearance (p 〉 0.5). The time integrals of unbound plasma fluorescein in the diabetics between the time of injection and 1 hour later were comparable with those of healthy controls. The difference between the mean PBRB value of diabetics with advanced retinopathy and that of a healthy population was significant (p 〈 0.003) but the difference for the mean values of diabetics with no or minimal background retinopathy was not (p 〉 0.2), indicating that PBRB values do not increase to an abnormal level while signs of diabetic retinopathy are absent on fluorescein angiography.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00155129
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