ISSN:
1573-9171
Keywords:
trans-3.4-diamino-2,2,6,6-tetramethylpiperidine-1-oxyl
;
diastereomeric derivatives, resolution
;
structure
;
absolute configuration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The reaction of 3,4-diamino-2,2,6,6-tetramethylpiperidine-1-oxyl with (1S)-(+)-camphor-10-sulfonyl chloride gives a mixture of diastereomeric 4-monosulfonylamino derivatives. The products of their acylation have been obtained. The 3,4-bis-[(1S)-camphor-10-sulfonylamino] derivative was synthesized and resolved to individual diastereomers. For one of them thetrans relationship of the 3- and 4-substituents and the absolute (3S,4R)-configuration were established by X-ray structural analysis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00697088
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