ISSN:
1573-9171
Keywords:
molecular structure
;
conformation
;
proline
;
hydrazone
;
diaziridine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The molecular structure of 3-methyl-1-((S)-1′-tosylprolyl)1,2-diazacyclohex-2-ene, the product of the reaction of 5-methyl-1,6-diazabicyclo[3.1.0]hexane with (S)-N-tosylproline chloride, has been established by X-ray structural analysis. The pyrrolidine cycle has a half-chair conformation with the pyramidal nitrogen atom; the tosyl and pseudo axial carbamoyl groups havetrans orientations. The diazacyclohexene cycle has an envelope conformation with folding along the C(7)...C(9) line. The stereochemistry of the transition state of the above-mentioned reaction is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00702393
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