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The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers (1989)

Philip, P. A. ; James, C. A. ; Rogers, H. J.

Springer

European journal of clinical pharmacology 36 (1989), S. 319-321

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ISSN: 1432-1041

Keywords: cimetidine ; debrisoquine ; drug interactions ; extensive metabolizers

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary We have studied the effect of cimetidine (800 mg·day−1) administration for three days on debrisoquine 4-hydroxylation in nine healthy extensive metabolizers. The debrisoquine metabolic ratio was significantly increased (p〈0.01), but the new ratios remained in the extensive metabolizer range (〈12.6). These data suggest that pre-treatment with cimetidine in usual therapeutic doses will impair debrisoquine 4-hydroxylation, but not enough to alter the apparent oxidation phenotype.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00558167

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