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  • 1
    Electronic Resource
    Electronic Resource
    Metabolism of methaqualone in geriatric patients (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 285-289 
    Details
    ISSN: 1432-1041
    Keywords: Methaqualone ; drug metabolism ; geriatric patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The urinary excretion of fiveC-monohydroxy metabolites and theN-oxide of methaqualone has been measured in a group of eleven geriatric patients aged 71–90 years. The total excretion of the six metabolites in 24 h after the oral administration of a single dose was approximately one-half of that in a group of young healthy adults. The relative importance of the six metabolites was 4′-hydroxy ≫N-oxide〉 2′-hydroxymethyl = 3′-hydroxy 〉 6-hydroxy = 2-hydroxymethyl which was the same order as that in young adults. The ratio ofC-toN-oxidation was also the same in the two groups. There was no impairment of conjugation of theC-hydroxy metabolites with glucuronic acid in the geriatric group but there was greater interindividual variation in metabolite excretion. There was also evidence for delayed metabolism in the geriatric patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716364
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The metabolism of methaqualone in patients with biliary cirrhosis or secondary carcinoma of the liver (1979)
    Springer
    European journal of clinical pharmacology 15 (1979), S. 57-61 
    Details
    ISSN: 1432-1041
    Keywords: Metaqualone ; biliary cirrhosis ; liver carcinoma ; drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolism of methaqualone has been studied in three patients with secondary carcinoma of the liver and two with biliary cirrhosis. The urinary excretion of fiveC-monohydroxy metabolites and theN-oxide was studies in the 24 h period immediately after oral dosing with 250 mg methaqualone (Melsed). In both patients with biliary cirrhosis and one with primary carcinoma of the bile duct or pancreas with secondaries in the liver the pattern of metabolites was normal. In a patient with oat cell carcinoma with secondaries in the liver some metabolite patterns were disturbed and increased metabolite excretion occurred. A patient with primary carcinoma of the breast with secondaries in the liver gave a completely abnormal metabolite pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563558
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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