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Augmentation of cysteamine-induced ulceration of rat duodenum by systemically administered γ-aminobutyric acid (GABA) (1989)

Krantis, Anthony ; Nicholson, Michelle

Springer

Digestive diseases and sciences 34 (1989), S. 1211-1216

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ISSN: 1573-2568

Keywords: γ-aminobutyric acid ; GABA ; cysteamine HCl ; duodenal ulcer ; rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Subcutaneous administration of a single dose of γ-aminobutyric acid (GABA, 10 mg/100 g) in conjunction with a pretreatment dose of aminooxyacetic acid (AOAA 2.5 mg/100 g subcutaneously) to prevent the degradation of GABA, significantly augmented the incidence and intensity of cysteamine HCl-induced duodenal ulceration in rats. This effect of GABA could be reduced by the GABA receptor antagonist, bicuculline (30 Μg/100 g subcutaneously). These results suggest peripheral GABA receptors can modulate cysteamine HCl-induced duodenal ulcer.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01537269

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