ISSN:
1573-7330
Keywords:
gamete intrafallopian transfer (GIFT)
;
pronuclear-stage transfer (PROST)
;
premature ovarian failure (POF)
;
micronized steroids
;
pronuclear
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This report describes both gamete intrafallopian transfer (GIFT) and pronuclear-stage transfer (PROST) of donated oocytes to patients with premature ovarian failure (POF), using micronized oral progesterone (P4) and lowdose micronized estradiol (E2) for endometrial preparation and maintenance. Patient A, with POF of 15 years' duration, received four donated oocytes for GIFT and subsequently delivered a normal, term, female infant. Patient B was diagnosed as POF 3 years ago. She received four donated oocytes, which were subsequently fertilized in vitro with husband's sperm. The following day, four pronuclear-stage embryos were transferred to her fallopian tubes. She recently delivered twin, healthy female infants. These procedures, along with exogenous hormonal development of the endometrium, provide a simplified means to establish and maintain pregnancy in POF patients. Both patients were maintained on lowdose micronized E2 prior to their procedure, Patient A on 3 mg E2 per day cyclically and Patient B on 0.5 mg E2 continuously. Micronized oral P4 was used to maintain pregnancy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01130781
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