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  • 1
    Electronic Resource
    Electronic Resource
    Protein binding investigation by difference circular dichroism: Native and acetylated human serum albumins (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 7 (1995), S. 57-61 
    Details
    ISSN: 0899-0042
    Keywords: protein binding ; circular dichroism ; human serum albumin ; stereoselectivity ; drugs ; modified albumin ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A modified albumin was prepared by selective reaction of Lys199 with acetyl salicylic acid. Protein binding investigation was carried out on native and modified proteins by difference circular dichroism (ΔCD). Acetylation of Lys199 reduces significantly the effects of the interaction between drugs in the stereoselective HSA binding at specific binding areas. © 1995 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530070202
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chiral discrimination promoted by (1S,2S)-1-phenyl-2-amino-1,3-propanediol derivatives in the asymmetric Reformatsky reaction (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 7 (1995), S. 499-504 
    Details
    ISSN: 0899-0042
    Keywords: optically active aminodiols ; chiral ligands ; enantioselective reaction ; enantiomeric excess ; chiral separation ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some 3-t-butyldimethylsilyloxy derivatives, synthesized from the cheap commercially available (1S,2S)-2-amino-1-phenyl-1,3-propanediol [(1S,2S)-1], have been successfully employed as new chiral ligands in the asymmetric Reformatsky reaction on aldehydic substrates. The influence both of the substrate and of the ligand on the stereochemical pathway has been investigated by varying the structure of the carbonyl substrate and of the optically active aminodiols. © 1995 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530070702
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Stereochemical features of 1,4-benzodiazepin-2-ones bound to human serum albumin: Difference CD and UV studies (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 2 (1990), S. 167-174 
    Details
    ISSN: 0899-0042
    Keywords: benzodiazepines ; circular dichroism ; difference spectroscopy ; human serum albumin ; stereospecific interaction ; chiral discrimination ; electronic absorption spectra ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The stereochemistry of an achiral (Diazepam) and two chiral (3-methyl and 3-succinyloxy substituted) 1,4-benzodiazepin-2-ones interacting with human serum albumin (HSA) has been investigated by making use of difference absorption (UV) and circular dichroism (CD) spectroscopies. Evidence is obtained for a higher affinity with HSA for one of the two possible conformations of the seven-membered benzodiazepine ring. The red shift revealed by the absorption difference spectrum between the free and the bound drug accounts for the CD difference spectra observed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530020308
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Circular dichroism detection in HPLC (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 3 (1991), S. 376-385 
    Details
    ISSN: 0899-0042
    Keywords: circular dichroism ; detection system ; chromatography ; chiral discrimination ; enantiomeric excess ; elution order ; dissymmetry factor ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A circular dichroism-based detection system presents several advantages in the HPLC analysis of chiral compounds because of the selective monitoring of optically active molecules. Its use allows reliable determination of enantiomeric excesses and elution order. To this end, the application of empirical, semiempirical, and nonempirical methods to get stereochemical information from the CD signal is reported. Furthermore, recording the CD spectra on line and evaluation of the dissymetry factor make the CD detection very powerful in characterizing the stereochemistry of chiral eluates.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530030424
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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