ISSN:
1572-994X
Keywords:
ICP18.5
;
DNA-binding protein (ICP8)
;
equine herpesvirus-1
;
herpesvirus
;
capsid maturation
;
gene cluster
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The genome of equine herpesvirus-1 (EHV-1) contained three open reading frames (ORFs) in a 3.9 kbpBamHI-SmaI fragment at 0.38–0.41 map units in the long unique region. The most 5′ ORF encoded the carboxy terminus of a protein with 45–55 percent amino acid homology to the DNA-binding proteins (ICP8-DBP) of four other alphaherpesviruses. The middle ORF translated to a polypeptide of 775 residues with 43–55% homology to the ICP18.5 proteins. The most 3′ ORF encoded the EHV-1 glycoprotein B (gB) gene. Three mRNAs of 4.3, 4.4–4.8, and 3.5–3.9 kb (corresponding to the three sequenced ORFs) were all transcribed from the same strand. The gene order of this group was conserved in all herpesviruses examined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01702583
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