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In vitro stability of proscillaridin A (1975)

Andersson, K. -E. ; Bertler, Å. ; Redfors, A.

Springer

European journal of clinical pharmacology 8 (1975), S. 135-139

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ISSN: 1432-1041

Keywords: Proscillaridin A ; digoxin ; 86Rb-assay ; stabilityin vitro ; gastric juice

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary In anin vitro study, proscillardin A was found to be rapidly inactivated at low pH. More than 50 per cent of its activity, measured by86Rb assay, was lost after incubation for 15 minutes at pH 1 and 37° C. Compared with proscillaridin, the rate of inactivation of digoxin was lower in these experiments. The rapid inactivation of proscillaridin might be of clinical importance when treating patients with this glycoside.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00561563

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