ISSN:
1573-2568
Keywords:
substance P
;
gastrointestinal transit in rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Thein vivo effect of substance P and related peptide analogs on gastrointestinal transit in unanesthetized rats was studied. Fasted male rats were given intragastrically 0.5 ml of a powdered charcoal (BaSo4·H2O) meal and were concomitantly injected intraperitoneally with 8 Μg/kg of substance P or a related peptide. In control rats, the percentage of small intestine traversed by the meal 15 min after feeding was 44.9±1.4 (N = 12). Substance P, [Glu6]SP6–11, [pGlu6, gPhe6, mGly9]SP6–11 and [pGlu5,N-MePhe8,N-MeGly9SP6–11, significantly accelerated intestinal transit: 59.5±3.1% (N=7); 66.0±3.8% (N=14), 66.8±2.4% (N=25), and 58.4±4.4% (N=4), respectively. Concomitant injection of [pGlu6SP6–11 and BOC-Phe-Phe-Gly-NHOH, an inhibitor of enzyme degradation at a dose of 800 Μg/kg lowered by 10-fold the dose of [pGlu6]SP6–11 needed to induce the same degree of intestinal transit acceleration. These results indicate that in rats, substance P and related peptides accelerate gastrointestinal transit.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01536634
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