ISSN:
1432-1041
Keywords:
Loperamide
;
Intestinal perfusion
;
absorption
;
transit time
;
healthy volunteers
;
intestinal transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Jejunal perfusion was performed in 12 healthy volunteers to evaluate the dose dependent effects of loperamide on intestinal absorption, stimulated secretion and transit. In 6 volunteers intestinal perfusion of the jejunal segment with isotonic NaCl solution was followed by addition of loperamide in increasing doses (2–8 mg·l−1). The volunteers were pretreated with 1 mg·l−1 prostaglandin E2 (PgE2) in the perfusate before addition of 4 mg·l−1 loperamide. Phenolsulphonphtalein (PSP) boluses (2 ml) were given to measure mean transit time (MTT). Loperamide 2 mg·l−1 converted the minor secretion after perfusion with the standard solution (water −1.45 ml·min−1, Na −0.09 and Cl −0.04 mmol·min−1) to absorption (water 0.93 ml·min−1, Na 0.23, Cl 0.25 mmol·min−1) within 15 min. Higher doses of loperamide did not increase absorption. The addition of PgE2 induced net secretion of water (−4.48 ml·min−1) and electrolytes (Na −0.57, Cl −0.51 mmol·min−1). Loperamide 4 mg·l−1 significantly diminished the PgE2-induced net secretion by approximately 50%. Loperamide dose dependently increased the MTT from 6 (2 mg·l−1) to 13.3 min (8 mg·l−1). MTT was still delayed 60 min after a wash out period (10.5 min). It is concluded that loperamide had a dual effect or intestinal activities stimulating absorption and prolonging intestinal transit time with rising doses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315436
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