ISSN:
1432-1041
Keywords:
alinidine
;
emotional stress
;
tachycardia
;
healthy volunteers
;
heart rate
;
blood pressure
;
forearm blood flow
;
St 567
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Experiments were performed in a randomized double blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally — induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542040
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