ISSN:
1572-8943
Keywords:
animal cells
;
calorimetry
;
cell signalling cascades
;
drug action
;
enthalpy balance
;
heat-flow rate
;
integrated circuits
;
therapeutic proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A formal explanation of Mayer's enthalpy balance method as applied to cell physiology is given with particular reference to striated muscle tissue. The approach is then extended to animal cells growing in a bioreactor, showing its use to optimise their growth and the production of therapeutic proteins, as well as defining the correct physiological conditions. Attention is then drawn to the value of the calorimetric-respirometric ratio in defining the anaerobic pathways operating simultaneously with respiration under fully aerobic conditions. An important field now is to resolve the metabolic costs of cell signalling cascades, an area that could demonstrate the coming importance of integrated circuit calorimetry.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1010199422705
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