ISSN:
1573-8221
Keywords:
MCD-peptide
;
mellitin
;
substance 48/80
;
mast cells
;
liberation of histamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The histamine-liberating action of MCD-peptide and of mellitin, isolated from bee venom, and of substance 48/80 was studied on isolated rat mast cells. The action of MCD-peptide is similar to that of the noncytotoxic agent 48/80 in the character of the dose-response curves, latent period, and temperature-dependence of histamine liberation. The liberation of histamine induced by MCD-peptide is an energy-dependent process but is independent of cyclic AMP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00798533
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