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  • 1
    Electronic Resource
    Electronic Resource
    Stereochemical features of 1,4-benzodiazepin-2-ones bound to human serum albumin: Difference CD and UV studies (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 2 (1990), S. 167-174 
    Details
    ISSN: 0899-0042
    Keywords: benzodiazepines ; circular dichroism ; difference spectroscopy ; human serum albumin ; stereospecific interaction ; chiral discrimination ; electronic absorption spectra ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The stereochemistry of an achiral (Diazepam) and two chiral (3-methyl and 3-succinyloxy substituted) 1,4-benzodiazepin-2-ones interacting with human serum albumin (HSA) has been investigated by making use of difference absorption (UV) and circular dichroism (CD) spectroscopies. Evidence is obtained for a higher affinity with HSA for one of the two possible conformations of the seven-membered benzodiazepine ring. The red shift revealed by the absorption difference spectrum between the free and the bound drug accounts for the CD difference spectra observed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530020308
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