ISSN:
1573-3904
Keywords:
mercury
;
metalloantibodies
;
metal panning agents
;
metals
;
phosphorodithioates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The design, synthesis and characterization of a new class of metal complexes (panning agents) for the selection of antibodies from a combinatorial library are described. The metal panning agents contain a phosphorodithioate moiety that binds soft metals, leaving them coordinatively unsaturated. Subsequent panning against an antibody phage library selects for members that recognize, and bind directly to, the metal rather than ligands attached to the metal.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008920201914
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