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  • 1
    Electronic Resource
    Electronic Resource
    Enantioselectivity of esterases in human brain (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 565-568 
    Details
    ISSN: 0899-0042
    Keywords: oxazepam ; oxazepam 3-acetate ; hydrolysis ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Subcellular fractions of three human brain specimens were found to contain esterase activities which hydrolyzed racemic oxazepam 3-acetate (rac-OXA). All three human brain preparations were highly selective toward the S-enantiomer of rac-OXA. © 1993 Wiley-Liss, Inc.This article is a US Government work and, as such, is in the public domain in the United States of America.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530050714
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enantioselectivity suggests a cytosolic origin for a commercial pig liver esterase preparation (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 7 (1995), S. 40-43 
    Details
    ISSN: 0899-0042
    Keywords: enantioselectivity ; pig liver esterase ; hydrolysis ; oxazepam ; chiral stationary phase HPLC ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A widely utilized pig liver esterase preparation has been found to be derived essentially exclusively from the cytosolic fraction of pig livers. Esterases in cytosol and microsomes prepared from a fresh pig liver hydrolyzed the S- and R-enantiomers of racemic oxazepam 3-acetate (rac-OXA) with specific activity ratios of approximately 2.3:1 and 1:62, respectively. Product formations were analyzed by chiral stationary phase high-performance liquid chromatography. The commercial pig liver esterase preparation showed greater activity toward S-OXA than did the esterases in the cytosolic fraction prepared from fresh pig liver. The results established that (i) esterases contained in microsomes and cytosol of pig liver have opposite enantioselectivity in the hydrolysis of rac-OXA and (ii) the commercial pig liver esterase preparation has a cytosolic origin. © 1995 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530070108
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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