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  • 1
    ISSN: 1432-0428
    Keywords: Blood glucose ; continuous blood glucose analysis ; diabetes therapy criteria ; unstable diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Individual blood glucose (BG) measurements at selected time points were compared with continuously recorded BG data as criteria of the adequacy of diabetes regulation. Indices reflecting the adequacy of diabetes regulation have previously been developed from continuously monitored BG measurements during studies under standardized near-normal living conditions. These indices are: (1) mean amplitude of glycemic excursions (MAGE), (2) diurnal mean blood glucose (MBG), (3) mean of daily differences of paired BG values (MODD). Because of the intensive studies necessary to obtain these indices, approximations based on individual BG measurements which might easily be obtained in practice were sought. The BG value 80 min after breakfast correlated best with the MAGE. The average of the fasting BG value and the value at 80 min after breakfast correlated well with the MBG. These individual BG measurements distinguished the groups of subjects. The difference between fasting BG values on successive days (AFBG) correlated well with the MODD. However, unlike MODD itself, AFBG did not distinguish the groups of subjects. Some other selected BG values with different timing were nearly equally highly correlated with these three criteria of BG behavior. Thus, relatively few but critically timed BG measurements on successive days, with suitable urinary glucose measurements, during standardized therapeutic programs may serve as an index of the efficacy of the therapy. By these same means, the characteristics of the patient's diabetes might also be assessed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 17 (1979), S. 5-16 
    ISSN: 1432-0428
    Keywords: Diabetic control ; HbAIc ; hyperglycaemia ; diabetes ; renal threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Control of diabetes from complete normalisation to less adequate degrees of metabolic regulation needs to be assessed with regard to conditions of evaluation and to severity of the disease. Under optimal conditions the therapeutic events should occur with well-timed regularity. Different assessment criteria are appropriate depending on the severity of the deficiency of endogenous insulin. Plasma and urine glucose and ketone body measurements remain the practical standards for assessing diabetic control. Abnormalities of lipid and protein metabolites serve to augment the scope of the assessment. Triglycerides and haemoglobin AIc are also useful indicators of control. In mild (Type II) diabetes it may be possible to achieve normal plasma glucose measurements two hours after meals. Such aims carry a risk of hypoglycaemia in severe (Type I) diabetes. Normoglycaemia and aglycosuria in severe diabetes are feasible only preprandially in most cases. The use of urine glucose tests requires evaluation of blood-to-urine glucose relationships. Practical and convenient methods for identifying patients with high or low “renal thresholds” are described. Investigational methods for characterising diabetic patients assess the variability of glucose and other variables during therapy, as well as the degree to which normal values are attained. Such assessment methods may gain increasing practical importance as therapeutic approaches to diabetic control which are experimental at present come into practice.
    Type of Medium: Electronic Resource
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