ISSN:
1573-8221
Keywords:
hypoxia
;
succinic semialdehyde-antihypoxic properties
;
ammonia and its metabolism
;
brain and liver tissue
;
reduced and oxidized NAD
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD · H2 by succinic semialdehyde and its derivatives with a free aldehyde group. The conversion of succinic semialdehyde and its derivatives in the liver tissue leading to the formation of the oxidized form of NAD, which is deficient in hypoxia, and the prevention of accumulation of free ammonia in the brain tissue by preliminary administration of succinic semialdehyde are the possible mechanisms of the antihypoxic properties of succinic semialdehyde and its derivatives.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00799318
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