ISSN:
1573-6830
Keywords:
corticotropin-releasing factor
;
immunosuppression
;
immunocytes
;
human
;
invertebrate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. Corticotropin-releasing factor (CRF) appears to be a potentially important signal molecule in both vertebrate and invertebrate neuroimmune and autoimmunoregulatory processes. It appears to mimic the effects ofα-melanocyte stimulating hormone (MSH) but has a longer duration of action. 2. α-Helical CRF, a specific inhibitor of CRF, antagonizes CRF-induced cellular immunosupression but is ineffective in altering MSH-induced immunosuppression. 3. Both human andMytilus immunocytes appear to have specific CRF receptors. 4. In another experiment, both CRF and MSH antagonize tumor necrosis factor stimulation of immunocytes. Again,α-helical CRF antagonizes only CRF activity, further suggesting the presence of a separate CRF receptor on these cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00711548
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