ISSN:
1432-0428
Keywords:
Pancreatic islet allograft
;
immunotherapy
;
anti-IL-2 RMAB
;
cyclosporin, graft histology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Since interleukin-2-receptor expressing cells play a role in allograft rejection, we investigated the effect of anti-interleukin-2 receptor monoclonal antibody treatment on graft survival of allografted pancreatic islets. When pancreatic islets obtained from Lewis A-rats (haplotype RT1a) were grafted under the kidney capsules of streptozotocin-diabetic Lewis rats (haplotype RT1u), the recipients relapsed into hyperglycaemia within 11 days (7±1 days). Treatment of the recipient rats with low-dose cyclosporin (1.5 mg/kg body weight) had no effect on allograft survival (9±1 days). The application of anti-interleukin-2 receptor monoclonal antibody (1mg/kg body weight) for 10 days resulted in a prolongation of allograft survival (42.5±15.3,p〈0.01). In 3 out of 11 animals a permanent normoglycaemia (〉120 days) associated with glucose intolerance was observed. When the recipients were treated for 10 days with cyclosporin and anti-interleukin-2 receptor monoclonal antibody, the allograft survival was also prolonged (45.1±14.6,p〈0.01); again 3 out of 11 animals remained permanently normoglycaemic while exhibiting a normal glucose tolerance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01788907
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