ISSN:
1573-8221
Keywords:
anxiety
;
substance P
;
diazepam-binding inhibitor
;
neuropeptide Y
;
stress
;
inbred rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The content of substance P in the hippocampus, hypothalamus, and midbrain of WAG/G rats surpassed these in Fischer-344 rats. After a 15-min stay in a shuttle box, the level of substance P in the hypothalamus and especially in the hippocampus decreased only in WAG/G rats. The content of diazepam-binding inhibitor in the hippocampus and midbrain of WAG/G rats was higher than in Ficher-344 rats. Stress increased the content of diazepam-binding inhibitor only in Fischer-344 rats. Midbrain content of neuropeptide Y in intact and stressed WAG/G rats was significantly lower than in Fischer-344 rats. There were no interstrain differences in the initial hypothalamic levels of neuropeptide Y between WAG/G and Fischer-344 rats. However, 15-min stress in the shuttle box increased hypothalamic content of neuropeptide Y only in Fischer-344 rats. Thus, high-anxiety rats are characterized by a low density of benzodiazepine receptors, decreased levels of substance P and diazepam-binding inhibitor, and high brain content of neuropeptide Y.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02438072
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