ISSN:
1573-8221
Keywords:
induction
;
phenobarbital
;
albumin
;
cytochrome P-450
;
immune response
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Definite interaction exists between the induction of microsomal enzymes and induction of the immune response to foreign substances. The loss by phenobarbital of its ability to induce the cytochrome P-450-hydroxylase system when bound covalently with albumin, coupled with the acquisition by phenobarbital of ability to induce a lymphocytic immune system reflects the ability of the two defensive systems of the body — hydroxylase and immune — to interact with foreign compounds of low and high molecular weight. The cytochrome P-450-hydroxylase system of the liver and other tissues is designed to protect the body against the action of low-molecular-weight hydrophobic compounds. The immune system is responsible for the protective effect against high-molecular-weight foreign substances.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00834241
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