ISSN:
1573-675X
Keywords:
apoptosis
;
death receptors
;
inflammation
;
reactive oxygen species (ROS)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009616228304
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