ISSN:
1432-0428
Keywords:
Type 2 (non-insulin-dependent) diabetes mellitus
;
mortality
;
urinary albumin excretion
;
risk factors
;
ischaemic heart disease
;
hypertension
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In 1981–1982 urinary albumin excretion rates were determined in 211 diabetic and 216 non-diabetic subjects aged 60–74 years. By April 1992 122 diabetic and 58 non-diabetic probands had died. Dividing the two study populations at an albumin excretion rate of 15 μg/min showed that 69.3% of diabetic subjects with values at or above the limit, and 49.9% of those with values below (log rank testp=0.0082) had died. The corresponding values for non-diabetic subjects were 44.4% and 21.0%, respectively (log rank testp=0.0002). In single factor log rank tests ischaemic heart disease and a low value of HDL were also predictive of death in the diabetic population during a 10–11-year observation period. In the non-diabetic population ischaemic heart disease, hypertension, and a serum creatinine level above the median value were predictive. In further log rank analyses probands dying during the first years, (e.g. the first 2 years) were removed from the calculations. The prognostic value of the above-mentioned factors diminished with time. In a Cox Regression analysis we found that the predictive value of urinary albumin excretion rate to mortality had disappeared when subjects who had died during the first 5 years were removed from the analysis, whereas HDL in the diabetic patients and blood pressure and serum creatinine in non-diabetic subjects were still of significant predictive value. We therefore conclude that urinary albumin excretion rate is a more short-term predictor of mortality than previously thought, in contrast to HDL, hypertension and serum creatinine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02374495
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