ISSN:
1569-8041
Keywords:
Hodgkin's disease
;
interleukin-10
;
prognosis
;
prognostic score
;
sCD30
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background:The International Prognostic Score (IPS) identifiesseven independent factors predicting progression-free and overall survival inadvanced stage Hodgkin's disease (HD). The IPS is also applicable in limiteddisease. However, the IPS does not identify patients with a very poorprognosis. The aim of this study was to define biological markers which mayadd to the IPS in predicting outcome. Patients and methods: One hundred forty-five patients (〉15years) with HD of all stages and histopathology subgroups were included. Inaddition to factors included in the IPS, serum levels of CRP, sCD4, sCD8,sCD25, sCD30, sCD54, interleukin (IL)-10, β2-microglobulin and thymidinekinase were analysed. Results:The strongest predictors of a poor cause-specificsurvival (CSS) in univariate analyses were: increased serum levels of IL-10,sCD30 and CRP, anaemia, low levels of albumin (P〈 0.001); stageIV (P= 0.003), age ≥45 years (P= 0.006), increasedserum levels of sCD25 (P= 0.010), low lymphocyte counts (P= 0.020). Serum IL-10 added prognostic information to that achieved bythe IPS: patients with a high score and increased serum IL-10 had a very pooroutcome with a five-year CSS of 38%. Patients with increased serumlevels of sCD30 and a high score also had a poor outcome with a five-year CSSof 54%. Conclusion:Serum levels of IL-10 and sCD30 may add to IPS inprediction of outcome in HD, and should be validated in large, prospectivestudies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026551727795
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