ISSN:
1420-9071
Keywords:
Antimutagens
;
natural product
;
unusual amino acids
;
isolation and structural determination
;
Liliaceae
;
Sapindaceae
;
Salmonella typhimurium TA100
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Five unusual amino acids were identified as antimutagens against spontaneous mutation ofSalmonella typhimurium TA100: L-azetidine-2-carboxylic acid (1) from Liliaceae plants, α-(methylenecyclopropyl)glycine (2) fromLitchi chinensis seeds, and 2-amino-4-methylhex-5-ynoic acid (3), hypoglycin A (4), and (2S, 4R)-2-amino-4-hydroxyhept-6-ynoic acid (5) fromEuphoria longana seeds. The absolute stereochemistry of5 was determined by its chiral synthesis from L-allylglycine, proving that5 is the C-4 epimer of the amino acid previously isolated from dried longan seeds.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01964840
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