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  • 1
    Electronic Resource
    Electronic Resource
    Streptozotocin diabetes: A glucoreceptor dysfunction affecting D cells as well as B and A cells (1979)
    Springer
    Diabetologia 17 (1979), S. 385-389 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; streptozotocin ; somatostatin release ; glucagon release ; isolated canine perfused pancreas ; glucoreceptor ; glucose ; arginine ; isoproterenol ; calcium ; radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Somatostatin release from the isolated pancreas of 3 normal and 6 streptozotocin diabetic dogs has been measured in response to various stimuli to determine whether abnormalities in somatostatin release are present in the diabetic pancreas. Simultaneous measurement of glucagon secretion was also made. In the pancreas from normal dogs increases in perfusate glucose from 25 to 200 mg/100 ml induced a 2–3 fold increase in somatostatin release and a two thirds decrease in glucagon secretion. In contrast, in the diabetic pancreas glucose caused no change in the secretion of the two hormones. In the diabetic pancreas addition of insulin to the perfusate (25,000 μU/ml) for periods from 10 to 75 minutes aimed at restoring normal extracellular insulin levels in the islets failed to restore either somatostatin or glucagon secretion to normal. In contradistinction to the lack of effect of glucose, the somatostatin and glucagon responses to arginine (5 mmol/l), isoproterenol (2 ng/ml) and calcium (5 mmol/l) were normal in the diabetic pancreas. The data suggests the presence of a selective glucoreceptor abnormality of the D as well as of B and A cells in the streptozotocin diabetic dog.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01236274
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterisation of somatostatin release from the pancreas (1979)
    Springer
    Diabetologia 16 (1979), S. 261-266 
    Details
    ISSN: 1432-0428
    Keywords: Perfused pancreas ; somatostatin ; insulin ; glucagon ; calcium ; acetylcholine ; glucose ; isoproterenol ; arginine ; radioimmunoassay ; dog pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of calcium on somatostatin secretion was investigated in the isolated, perfused canine pancreas preparation and compared with those of acetylcholine, glucose, isoproterenol and arginine. Calcium (5 mmol/l) stimulated somatostatin release in a typical biphasic response pattern being about 5 times as potent as acetylcholine (1 μmol/l), arginine (5 mmol/l), and isoproterenol (2 ng/ml) while the release of insulin and glucagon in response to calcium and the other secretagogues were of the same magnitude. Somatostatin release increased progressively when perfusate calcium was increased step-wise from 0 through 1.25 and 2.5 to 5.0 mmol/l. Calcium stimulated the secretion of somatostatin in the absence of glucose. The stimulatory effect of calcium was, however, modulated by the glucose concentration being about twice as large at 200 mg/100 ml as at 25 mg/100 ml glucose in the perfusion medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221953
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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