ISSN:
1432-0428
Keywords:
Spontaneously diabetic mice
;
non-obese diabetic mice
;
kidney glycosidase activities
;
α- & β-glycosidase
;
parabiosis
;
diabetic control
;
diabetes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Spontaneously diabetic non-obese mice of the ICR strain were newly inbred in Shionogi laboratory, Japan. Animals became diabetic suddenly, more frequently and severely in females. Blood glucose levels were 452±73 mg/100 ml with serum insulin levels of 〈 1.0 μU/ml in the fed state. Parabiosis with normal control ICR mice for 2 weeks decreased the blood glucose level to 260±51 mg/ 100ml (P〈0.01) and resulted in serum insulin levels of 46.0±18.0 μU/ml (P〈0.01). Kidney homogenate β-N-acetylglucosaminidase and β-galactosidase activities were reduced in diabetic mice (42% and 44% decrease respectively) (P〈0.025 and P〈0.001), and restored almost to normal after 2 weeks of parabiosis. Renal α-mannosidase activity was decreased 43% (P〈0.001) in the diabetic mice but unaffected by parabiosis. Serum β-N-acetylglucosaminidase, β-galactosidase and α-glucosidase activities were significantly increased in diabetic mice (179%; 233% and 58% increase respectively) (P〈0.005, P〈0.001 and P〈0.001), and returned to normal with parabiosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00258311
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