ISSN:
1573-8744
Keywords:
sulfobromophthalein (BSP)
;
kinetics
;
BSP disposition
;
mathematical model
;
flow-limited
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A linear, flow-limited mathematical model of drug kinetics was used to simulate total sulfobromophthalein (BSP) kinetics in normal anesthetized rats during intravenous infusions and following rapid intravenous injections. Four parameters were used to characterize the distribution and biliary and urinary excretion of BSP: liver- to- plasma concentration ratio, extrahepatic tissue- to- plasma concentration ratio, liver clearance rate constant, and renal plasma clearance rate constant. The same parameters appear to characterize the kinetics of BSP in man through the successful application of “scale- up” techniques utilizing data from experiments in rats. Plasma levels of BSP corresponding to intravenous infusions and rapid intravenous injections in man are approximated by computer simulation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01066923
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