ISSN:
1573-2568
Keywords:
aspirin
;
mucosal injury
;
vitamin E
;
lipid peroxidation
;
adhesion molecule
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We investigated the effect of vitamin E on aspirin-induced gastric mucosal injury in rats. Twenty-eight male Sprague-Dawley rats were divided into four groups and were fed for 20 weeks with a diet containing 〈0.1 mg/100 g of α-tocopherol (vitamin E-deficient), 2 mg/100 g of α-tocopherol (normal and vitamin E-sufficient), or 50 mg/100 g of α-tocopherol (vitamin E-supplemented). In vitamin E-deficient rats, oral administration of aspirin (200 mg/kg) plus HCl created more severe hemorrhagic erosions than in other rats. Vitamin E-deficient rats had higher levels of thiobarbituric acid reactive substances, myeloperoxidase activity, and cytokine-induced neutrophil chemoattractant in the gastric mucosa. Flow cytometry showed that CD18 expression on stimulated neutrophils was higher in vitamin E-deficient rats than in vitamin E-supplemented rats. These results suggest that vitamin E protects against aspirin-induced gastric mucosal injury by inhibiting lipid peroxidation and accumulation of activated neutrophils.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005417929009
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