ISSN:
1435-1463
Keywords:
Keywords: Chemotherapy
;
lithium
;
neurotoxicity
;
vinca alkaloids.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP. Vinca alkaloids induce peripheral neuropathy and muscle damage. The molecular basis of this neurotoxicity has not been fully explained, but a possible role of neurofibrillary degeneration has been reported. We studied both in animals and in humans, whether Li is able to antagonise vinca alkaloid neurotoxicity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007020050180
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