ISSN:
1573-8744
Keywords:
hepatic clearance
;
extraction ratio
;
local anesthetics
;
pharmacokinetics
;
lidocaine
;
bupivacaine
;
etidocaine
;
cardiovascular effects of local anesthetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Two independent methods of calculating hepatic drug clearance were applied to data from studies of the human pharmacokinetics of lidocaine, bupivacaine, and etidocaine. Within experimental limitations, agreement was good between estimates obtained by measurement of areas under blood drug concentration-time curves after rapid intravenous injection and by direct measurement of arterial and hepatic venous drug concentrations. Apparent hepatic extraction ratios of the agents followed the order etidocaine (∼0.73)/s〉lidocaine (∼0.68〉bupivacaine (∼0.37).Pharmacokinetic implications of increases in hepatic blood flow induced by the agents are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01066215
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