ISSN:
1619-7089
Keywords:
Medullary thyroid carcinoma
;
Scintigraphy
;
Radiolabeled anti-calcitonin
;
mIBG
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Radiolabeled anti-calcitonin (CT) immunoglobulin fragments (131I-anti-CT F(ab′)2) and meta-iodobenzylguanidine (131I-mIBG) were injected into nude mice with a transplanted medullary thyroid carcinoma (MCT). 131I-Anti-CT F(ab′)2 proved to be unsuitable for MCT scintigraphic imaging. However, a high mIBG uptake was observed in MCTs, but not in control tumors (mesothelioma). The uptake of mIBG was not modified by the presence of reserpine or pentagastrine. These results are discussed, and it is suggested that mIBG could be an APUD-system marker.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00279068
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