ISSN:
1573-7241
Keywords:
adrenal renin
;
mRNA renin
;
potassium loading
;
nephrectomy
;
Dahl rat
;
hypertension
;
angiotensin II
;
converting enzyme inhibitor
;
prorenin
;
aldosterone
;
sodium depletion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The complete renin-angiotensin system is present in the adrenal cortex; prorenin, renin, angiotensinogen, angiotensin I and II, and converting enzyme. Most of the renin found is probably synthesized there since the renin concentration increases after nephrectomy, and the mRNA for renin is present. The renin-angiotensin system has the highest activity in the zona glomerulosa cells, the site of aldosterone formation. A low-sodium dist or a high-potassium diet, or nephrectomy markedly inereases the adrenal renin concentration in the zona glomerulosa cells without any effect on the fasciculata-medullary cells. There is a close correlation between adrenal renin and aldosterone production. The adrenal renin angiotensin system may be a local regulator of aldosterone production.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00051184
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