ISSN:
1573-8744
Keywords:
furazlocillin acylureido penicillin
;
stability
;
microbiological
;
high pressure liquid chromatography assays
;
red cell partitioning
;
plasma protein binding
;
healthy humans
;
posture independent
;
dose dependent pharmacokinetics of disposition
;
pharmacokinetics of the penicilloic acid derivative
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The pharmacokinetics of the novel acylureidopenicillin furazlocillin, 6-[D-2-(3-furfurylidenamino-2-oxo-imidazolidine-1-carboxamido)-2-(4-hydroxyphenyl)-acetamido]-penicillanic acid and of its penicilloic acid derivative were investigated in five healthy male volunteers after intravenous administration of 2 and 4 g dosages. The volunteers were either in a lying or sitting position throughout the duration of the studies. The concentrations of the drug in plasma and urine were measured by two different methods in parallel: a microbiological assay and a newly developed high pressure liquid chromatography method. The latter method was also applicable for quantitation of the penicilloic acid derivative in these biological fluids. The drug's plasma protein binding (66%) and apparent red cell-plasma partition coefficient (0.055) were concentration independent. The pharmacokinetics of the drug were first order only at the lower dose level The apparent half lives of three distinguishable phases were, respectively, 4 $$(t_{1/2_1 } )$$ , 18 $$(t_{1/2_2 } )$$ , and 64 $$(t_{1/2_z } )$$ .
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01061765
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