ISSN:
1573-0972
Keywords:
DNA transcription
;
evolution
;
phage
;
prokaryotes
;
RNA polymerase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract The essential role of DNA-dependent RNA polymerases in gene expression and the fact that the multimeric species are highly conserved throughout nature makes these enzymes a particular fascinating area of study. Here we shall review the conservation of structures and their relationship to function, especially in the multimeric eubacterial RNA polymerases, paying particular attention to the β core subunit and to recent studies of σ-factors of both the σ 70 and σ 54 families. We shall conclude with a brief consideration of phage-encoded RNA polymerases and phage-mediated modification of the host enzyme, and of the evolution of RNA-synthesising enzymes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00328028
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