Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Physiologic model for the pharmacokinetics of 2′deoxycoformycin in normal and leukemic mice (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 519-534 
    Details
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; physiologic model ; 2′deoxycoformycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A flow-limited physiologic mathematical model has been developed to describe the time course of 2′deoxycoformycin (2′dCF) concentrations in the plasma and tissues of mice following iv and ip doses. Urinary excretion is modeled as a linear process involving filtration and secretion, since kidney clearance exceeded estimated glomerular filtration rate. Intracellular binding is described as the sum of linear nonspecific binding plus strong saturable binding to adenosine deaminase. Pharmacokinetic parameters are determined by a sequential optimization scheme in which each tissue is studied by means of a hybrid model. The model has been used to predict pharmacokinetic behaviour of 2′dCF in both normal and leukemic mice, and model simulations are compared with published data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061024
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Relationship between genetic variation in thermal stability and electrophoretic mobility of mouse β-galactosidase (1978)
    Springer
    Biochemical genetics 16 (1978), S. 1007-1014 
    Details
    ISSN: 1573-4927
    Keywords: β-galactosidase ; mouse ; structural variation ; thermal stability ; electrophoretic mobility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We have examined the relationships between the genetic determinants for mouse β-galactosidase heat stability and electrophoretic mobility, in order to clarify previous reports indicating that a variation for enzyme heat stability is restricted to kidney while that for electrophoretic mobility is expressed in all tissues. We find that the two phenotypes show concordant strain distributions and cosegregate in genetic crosses. In contrast to a previous report, the thermal stability variation is expressed in all tissues, although the absolute rate of enzyme inactivation is tissue specific. The evidence supports the notion that a single β-galactosidase structural locus is expressed in all tissues and that the differences in enzyme stability between tissues results from posttranslational enzyme modification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00483750
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Assignment of a gene encoding ornithine decarboxylase to the proximal region of chromosome 12 in the mouse (1989)
    Springer
    Biochemical genetics 27 (1989), S. 745-753 
    Details
    ISSN: 1573-4927
    Keywords: mouse ; ornithine decarboxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthetic pathway, is encoded by at least one member of a multi-gene family in the mouse. Analysis of a polymorphism in ODC structure in recombinant inbred strains has enabled assigning a functional ODC structural gene (Odc) to the proximal region of mouse chromosome 12 betweenApob andEs25. Linkage ofOdc toApob andAh is conserved in the mouse and human genomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553994
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Assignment of a gene encoding ornithine decarboxylase to the proximal region of chromosome 12 in the mouse (1989)
    Springer
    Biochemical genetics 27 (1989), S. 745-753 
    Details
    ISSN: 1573-4927
    Keywords: mouse ; ornithine decarboxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthetic pathway, is encoded by at least one member of a multi-gene family in the mouse. Analysis of a polymorphism in ODC structure in recombinant inbred strains has enabled assigning a functional ODC structural gene (Odc) to the proximal region of mouse chromosome 12 betweenApob andEs25. Linkage ofOdc toApob andAh is conserved in the mouse and human genomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02396065
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Physiological pharmacokinetic modeling ofcis-dichlorodiammineplatinum(II) (DDP) in several species (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 131-155 
    Details
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; physiological model ; cisplatin ; DDP ; cis-dichlorodiammineplatinum(II)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A physiological pharmacokinetic analysis ofcis-dichlorodiammineplatinum(II) (DDP) is presented for the rabbit, dog, and human. The results are compared to a previous analysis for the rat. DDP binds irreversibly to low-molecular weight nucleophiles and macromolecules to form mobile and fixed metabolites at rates which are tissue-specific. The rate constant for the formation of fixed metabolite in plasma, determined by in vitro incubation, ranges from 0.004 to 0.008 min−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01065258
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Physiological pharmacokinetic parameters for cis-dichlorodiammineplatinum(II) (DDP) in the mouse (1992)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 20 (1992), S. 95-99 
    Details
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; physiological model ; cisplatin ; DDP ; cis-dichlorodiammineplatinum(II)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01143187
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...